The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress
Identifieur interne : 000495 ( Main/Exploration ); précédent : 000494; suivant : 000496The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress
Auteurs : A-Young Kim ; Jong Bok Seo ; Won-Tae Kim [Corée du Sud] ; Hee Jeong Choi ; Soo-Young Kim ; Genevieve Morrow ; Robert M. Tanguay ; Hermann Steller [États-Unis] ; Young Ho KohSource :
- BMC Genomics [ 1471-2164 ] ; 2015.
Abstract
Dystonia1 (DYT1) dystonia is caused by a glutamic acid deletion (ΔE) mutation in the gene encoding Torsin A in humans (HTorA). To investigate the unknown molecular and cellular mechanisms underlying DYT1 dystonia, we performed an unbiased proteomic analysis.
We found that the amount of proteins and transcripts of an Endoplasmic reticulum (ER) resident chaperone Heat shock protein cognate 3 (HSC3) and a mitochondria chaperone Heat Shock Protein 22 (HSP22) were significantly increased in the HTorAΔE– expressing brains compared to the normal HTorA (HTorAWT) expressing brains. The physiological consequences included an increased susceptibility to oxidative and ER stress compared to normal HTorAWT flies. The alteration of transcripts of Inositol-requiring enzyme-1 (IRE1)-dependent spliced X box binding protein 1(Xbp1), several ER chaperones, a nucleotide exchange factor, Autophagy related protein 8b (ATG8b) and components of the ER associated degradation (ERAD) pathway and increased expression of the Xbp1-enhanced Green Fluorescence Protein (eGFP) in HTorAΔE brains strongly indicated the activation of the unfolded protein response (UPR). In addition, perturbed expression of the UPR sensors and inducers in the HTorAΔE
Taken together, these data show that HTorAΔE in
The online version of this article (doi:10.1186/s12864-015-1518-0) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12864-015-1518-0
PubMed: 25903460
PubMed Central: 4415242
Affiliations:
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Tanguay</name><affiliation><nlm:aff id="Aff5">Department of Molecular Biology, Medical Biochemistry & Pathology, Université Laval, Québec, Qc G1V 0A6 Canada</nlm:aff><wicri:noCountry code="subfield">Qc G1V 0A6 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Steller, Hermann" sort="Steller, Hermann" uniqKey="Steller H" first="Hermann" last="Steller">Hermann Steller</name><affiliation wicri:level="2"><nlm:aff id="Aff6">Howard Hughes Medical Institute, the Rockefeller University, New York, NY 10065 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Howard Hughes Medical Institute, the Rockefeller University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Koh, Young Ho" sort="Koh, Young Ho" uniqKey="Koh Y" first="Young Ho" last="Koh">Young Ho Koh</name><affiliation><nlm:aff id="Aff1">ILSONG Institute of Life Science, Hallym University, 1605-4 Gwanyangdong, 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Gyeonggido 431-060 Republic of Korea</nlm:aff><wicri:noCountry code="subfield">Gyeonggido 431-060 Republic of Korea</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Department of Biomedical Gerontology, Graduate School of Hallym University, Chuncheon, Gangwon-do 200-702 Republic of Korea</nlm:aff><wicri:noCountry code="subfield">Gangwon-do 200-702 Republic of Korea</wicri:noCountry></affiliation></author><author><name sortKey="Seo, Jong Bok" sort="Seo, Jong Bok" uniqKey="Seo J" first="Jong Bok" last="Seo">Jong Bok Seo</name><affiliation><nlm:aff id="Aff3">Korea Basic Science Institute, Sungbuk-gu, Seoul 136-713 Republic of Korea</nlm:aff><wicri:noCountry code="subfield">Seoul 136-713 Republic of Korea</wicri:noCountry></affiliation></author><author><name sortKey="Kim, Won Tae" sort="Kim, Won Tae" uniqKey="Kim W" first="Won-Tae" last="Kim">Won-Tae Kim</name><affiliation wicri:level="1"><nlm:aff id="Aff4">National Academy of Agricultural Science, Rural Development Administration, Suwon, 441-707 Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Academy of Agricultural Science, Rural Development Administration, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Hee Jeong" sort="Choi, Hee Jeong" uniqKey="Choi H" first="Hee Jeong" last="Choi">Hee Jeong Choi</name><affiliation><nlm:aff id="Aff1">ILSONG Institute of Life Science, Hallym University, 1605-4 Gwanyangdong, Dongan-gu, Anyang, Gyeonggido 431-060 Republic of Korea</nlm:aff><wicri:noCountry code="subfield">Gyeonggido 431-060 Republic of Korea</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Department of Biomedical Gerontology, Graduate School of Hallym University, Chuncheon, Gangwon-do 200-702 Republic of Korea</nlm:aff><wicri:noCountry code="subfield">Gangwon-do 200-702 Republic of Korea</wicri:noCountry></affiliation></author><author><name sortKey="Kim, Soo Young" sort="Kim, Soo Young" uniqKey="Kim S" first="Soo-Young" last="Kim">Soo-Young Kim</name><affiliation><nlm:aff id="Aff3">Korea Basic Science Institute, Sungbuk-gu, Seoul 136-713 Republic of Korea</nlm:aff><wicri:noCountry code="subfield">Seoul 136-713 Republic of Korea</wicri:noCountry></affiliation></author><author><name sortKey="Morrow, Genevieve" sort="Morrow, Genevieve" uniqKey="Morrow G" first="Genevieve" last="Morrow">Genevieve Morrow</name><affiliation><nlm:aff id="Aff5">Department of Molecular Biology, Medical Biochemistry & Pathology, Université Laval, Québec, Qc G1V 0A6 Canada</nlm:aff><wicri:noCountry code="subfield">Qc G1V 0A6 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Tanguay, Robert M" sort="Tanguay, Robert M" uniqKey="Tanguay R" first="Robert M" last="Tanguay">Robert M. Tanguay</name><affiliation><nlm:aff id="Aff5">Department of Molecular Biology, Medical Biochemistry & Pathology, Université Laval, Québec, Qc G1V 0A6 Canada</nlm:aff><wicri:noCountry code="subfield">Qc G1V 0A6 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Steller, Hermann" sort="Steller, Hermann" uniqKey="Steller H" first="Hermann" last="Steller">Hermann Steller</name><affiliation wicri:level="2"><nlm:aff id="Aff6">Howard Hughes Medical Institute, the Rockefeller University, New York, NY 10065 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Howard Hughes Medical Institute, the Rockefeller University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Koh, Young Ho" sort="Koh, Young Ho" uniqKey="Koh Y" first="Young Ho" last="Koh">Young Ho Koh</name><affiliation><nlm:aff id="Aff1">ILSONG Institute of Life Science, Hallym University, 1605-4 Gwanyangdong, Dongan-gu, Anyang, Gyeonggido 431-060 Republic of Korea</nlm:aff><wicri:noCountry code="subfield">Gyeonggido 431-060 Republic of Korea</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Department of Biomedical Gerontology, Graduate School of Hallym University, Chuncheon, Gangwon-do 200-702 Republic of Korea</nlm:aff><wicri:noCountry code="subfield">Gangwon-do 200-702 Republic of Korea</wicri:noCountry></affiliation></author></analytic><series><title level="j">BMC Genomics</title><idno type="eISSN">1471-2164</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Dystonia1 (DYT1) dystonia is caused by a glutamic acid deletion (ΔE) mutation in the gene encoding Torsin A in humans (HTorA). To investigate the unknown molecular and cellular mechanisms underlying DYT1 dystonia, we performed an unbiased proteomic analysis.</p></sec><sec><title>Results</title><p>We found that the amount of proteins and transcripts of an Endoplasmic reticulum (ER) resident chaperone Heat shock protein cognate 3 (HSC3) and a mitochondria chaperone Heat Shock Protein 22 (HSP22) were significantly increased in the HTorA<sup>ΔE</sup>– expressing brains compared to the normal HTorA (HTorA<sup>WT</sup>) expressing brains. The physiological consequences included an increased susceptibility to oxidative and ER stress compared to normal HTorA<sup>WT</sup> flies. The alteration of transcripts of Inositol-requiring enzyme-1 (IRE1)-dependent spliced X box binding protein 1(Xbp1), several ER chaperones, a nucleotide exchange factor, Autophagy related protein 8b (ATG8b) and components of the ER associated degradation (ERAD) pathway and increased expression of the Xbp1-enhanced Green Fluorescence Protein (eGFP) in HTorA<sup>ΔE</sup> brains strongly indicated the activation of the unfolded protein response (UPR). In addition, perturbed expression of the UPR sensors and inducers in the HTorA<sup>ΔE</sup><italic>Drosophila</italic> brains resulted in a significantly reduced life span of the flies. Furthermore, the types and quantities of proteins present in the anti-HSC3 positive microsomes in the HTorA<sup>ΔE</sup> brains were different from those of the HTorA<sup>WT</sup> brains.</p></sec><sec><title>Conclusion</title><p>Taken together, these data show that HTorA<sup>ΔE</sup> in <italic>Drosophila</italic> brains may activate the UPR and increase the expression of HSP22 to compensate for the toxic effects caused by HTorA<sup>ΔE</sup> in the brains.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s12864-015-1518-0) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mcnaught, Ksp" uniqKey="Mcnaught K">KSP McNaught</name></author><author><name sortKey="Kapustin, A" uniqKey="Kapustin A">A Kapustin</name></author><author><name sortKey="Jackson, T" uniqKey="Jackson T">T 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uniqKey="Porter J">JC Porter</name></author><author><name sortKey="Ricketts, Jc" uniqKey="Ricketts J">JC Ricketts</name></author><author><name sortKey="Fox, Sa" uniqKey="Fox S">SA Fox</name></author><author><name sortKey="Nery, Fc" uniqKey="Nery F">FC Nery</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Choi, Hee Jeong" sort="Choi, Hee Jeong" uniqKey="Choi H" first="Hee Jeong" last="Choi">Hee Jeong Choi</name><name sortKey="Kim, A Young" sort="Kim, A Young" uniqKey="Kim A" first="A-Young" last="Kim">A-Young Kim</name><name sortKey="Kim, Soo Young" sort="Kim, Soo Young" uniqKey="Kim S" first="Soo-Young" last="Kim">Soo-Young Kim</name><name sortKey="Koh, Young Ho" sort="Koh, Young Ho" uniqKey="Koh Y" first="Young Ho" last="Koh">Young Ho Koh</name><name sortKey="Morrow, Genevieve" sort="Morrow, Genevieve" uniqKey="Morrow G" first="Genevieve" last="Morrow">Genevieve Morrow</name><name sortKey="Seo, Jong Bok" sort="Seo, Jong Bok" uniqKey="Seo J" first="Jong Bok" last="Seo">Jong Bok Seo</name><name sortKey="Tanguay, Robert M" sort="Tanguay, Robert M" uniqKey="Tanguay R" first="Robert M" last="Tanguay">Robert M. Tanguay</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Kim, Won Tae" sort="Kim, Won Tae" uniqKey="Kim W" first="Won-Tae" last="Kim">Won-Tae Kim</name></noRegion></country><country name="États-Unis"><region name="État de New York"><name sortKey="Steller, Hermann" sort="Steller, Hermann" uniqKey="Steller H" first="Hermann" last="Steller">Hermann Steller</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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